Inhibition of Porphyromonas gingivalis biofilm by oxantel.
نویسندگان
چکیده
Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivalis in biofilm than metronidazole, a commonly used antibiotic for periodontitis.
منابع مشابه
Click scaffolds for the inhibition of Porphyromonas gingivalis and Streptococcus gordonii biofilm formation
CLICK SCAFFOLDS FOR THE INHIBITION OF PORPHYROMONAS GINGIVALIS AND STREPTOCOCCUS GORDONll BIOFILM FORMATION Catherine M. Loner April 18,2012 Periodontitis and its systemic sequelae remain a major public health problem and developing a cost-efficient therapy will benefit healthcare worldwide. Adherence of Porphyromonas gingivalis to Streptococcus gordonii facilitates colonization ofthe oral cavi...
متن کاملAn Investigation of Antibiotic Resistance of Aggregatibacter Actinomycetemcomitans and Porphyromonas Gingivalis in Peri-implantitis Lesions
Background and Aim: It has been shown that anaerobic and capnophilic bacteria play an important role in implant failure and loss. The present study is an in vitro research aimed to investigate the antibiotic resistance of Aggregatibacter actinomycetemcomi-tans (Aa) and Porphyromonas gingivalis (Pg) in peri-implantitis lesions of Iranian pa-tients and to find laboratory efficiency of some antibi...
متن کاملPorphyromonas gingivalis and Treponema denticola Synergistic Polymicrobial Biofilm Development
Chronic periodontitis has a polymicrobial biofilm aetiology and interactions between key bacterial species are strongly implicated as contributing to disease progression. Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia have all been implicated as playing roles in disease progression. P. gingivalis cell-surface-located protease/adhesins, the gingipains, have been suggested...
متن کاملEffect of azithromycin on a red complex polymicrobial biofilm
Azithromycin has recently gained popularity for the treatment of periodontal disease, despite sparse literature supporting efficiency in treating periodontal bacterial biofilms. The aim of this study was to evaluate the effect of azithromycin on biofilms comprised of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia in comparison to an amoxicillin and metronidazole combina...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 54 3 شماره
صفحات -
تاریخ انتشار 2010