Inhibition of Porphyromonas gingivalis biofilm by oxantel.

نویسندگان

  • Stuart Dashper
  • Ching-Seng Ang
  • Sze Wei Liu
  • Rita Paolini
  • Paul Veith
  • Eric Reynolds
چکیده

Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivalis in biofilm than metronidazole, a commonly used antibiotic for periodontitis.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 54 3  شماره 

صفحات  -

تاریخ انتشار 2010